Проф. Тодор Кантарджиев: COVID ваксината е безопасна

neon7
преди 3 години "Доказано е, че създадените ваксини действат включително и срещу "британския" вариант`Vaccine News: Pfizers Study On Vaccine Effectiveness Against New VariantsAnd Claims are Misleading, Numerous Professional Experts Aghast.Pfizer and BioNTech announced on Friday that their COVID-19 vaccine is effective against the emerging variants. https://***.pfizer.com/news/press-release/press-release-detail/vitro-study-shows-pfizer-biontech-covid-19-vaccine-elicitsMany so called independent experts said the findings were good news, and the media was abuzz with news that the Pzifer vaccineswere effective against new strains including the B.1.1.7 strains and even the new South Africa variants.Pzifers PR team capitalized on their preprint study that has yet to be peer reviewed https://***.biorxiv.org/content/10.1101/2021.01.07.425740v1 and sadly, many media that we once though were reliable and credible including the New York Times and STATS News etcwent along and agreed with the claims.The big problem is that Pfizer only focused on one mutation found in the variant and that too it was just an in vitro study. In the human body,the dynamics of immune and antibody responses are much more complicated.It must be stressed here that these new variants including the B.1.1.7 contains as much as 23 mutations with a sizeable quantity just onthe spike proteins alone. https://***.thailandmedical.news/news/u-s-cdc-indicates-that-vaccines-might-not-protect-against-new-ukvariant-b-1-1-7-new-details-show-new-variant-could-be-the-expected-super-strainNumerous experts are commenting about the misleading study and also the misleading media coverages.Professor in Medicine, The Norwich School of Medicine, University of East Anglia, Prof Dr Paul Hunter said, The authors say no reductionin neutralization activity against the virus bearing the Y501 spike. But looking at figure 1 it does seem to me that there is a reduction of asingle dilution in the assay in about a half of all *** tested. The authors have helpfully drawn lines for those *** that did exhibit differentinhibition titres between the two variants. How is this figure compatible with the statement? I suspect the issue is that when comparing asingle serum or paired *** we generally need a twofold change to be sure so on any one serum a one fold difference would not be takenas being significant. But when looking at multiple *** then a one fold decline in titre in about half of cases and only one increased titres inthe remaining does suggest an impact.He added, Sometimes you get the appearance of an escape mutant (antigenic shift for influenza) that renders all its daughter virusesresistant to pre-existing immunity. Often you get a build up over time of small mutations (antigenic drift for influenza) that gradually producedaughters with increasing resistance. It does seem to me that this preprint does suggest a small increase in resistance to vaccineproduced antibodies, that even if not sufficient in itself could in combination with other mutants be an important step on the pathway toreduce the efficacy of pre-existing vaccines.Dr Hunter further commented, The other issue is that a recent preprint 1 found that the most important mutation giving resistance toimmunity following natural infection may be at E484 which is a mutation in the South African variant which of course would not be covered bythe preprint by Xie et al. and as far as I can tell by the preprint by Sahin to which Xie refers 2 . However, it is not clear to me whether the E484site is important in immunity with existing vaccines, but this needs to be confirmed. So at present the jury is still out on the impact of the SouthAfrican variant on vaccine efficacy. It is likely that vaccines will still be effective but maybe a little less so unless of course additional variantsarise.1 https://***.biorxiv.org/content/10.1101/2020.12.31.425021v12 https://***.medrxiv.org/content/10.1101/2020.12.09.20245175v1Professor of Microbiology at the University of Cambridge, Prof Dr Ravi Gupta, said, The short report, showing a single Spike mutation haslittle impact against serum from individuals vaccinated with the Pfizer vaccine, is misleading for a number of reasons. Firstly, the mutationselected is only one of 8 in the UK variant, and in fact was not expected to have significant impact alone. Secondly, primary titration curvesare not presented so one cannot see how well the experiments worked and what the measurement error was. The number of times theexperiments were repeated is not given. This work should be ignored until properly conducted work is made available. The present paperwould not pass peer review in its current form.Professor in Molecular Immunology, London Metropolitan University, Prof Gary McLean, said, Its a very short paper, not really even a paper just some experiments written up into a communication. However, they made mutant SARSCoV2 viruses with wild type N501 or the Y501spike variations and have shown that 20 *** from previously vaccinated people can still neutralize the virus in vitro and in fact is equivalenti.e. both variants were neutralized equally by *** from people immunized with the N501 variant. *** was obtained 2 and 4 weeks after thestandard two dose regimen presumably separated by 3 weeks as per guidelines (not the UK lets give as many the first dose and theneventually get around to the second dose regimen). This could be critical. The limitation is that they did not construct SARS-CoV-2 with thefull set of spike mutations in the UK variant and therefore further conclusions cannot be made fully at this stage.Chair of the British Society for Immunology COVID-19 and Immunology taskforce, and Professor of Immunology at University of Surrey, ProfDeborah Dunn-Walters said, A limitation of this study is that the mutation was tested in isolation. Where evidence, such as structuralmodeling, indicates that mutations could interact with each other to affect the overall antigen structure they should be tested together.Most media covering medical and health news should actually get writers are properly qualified to write about medical and health matterspreferably with a biology science or medical background and not some stupid journalist who do not understand anything about medicalmatters and are easily bought for small sums of money by some of these PR agencies.The public should be wary of also where they get their medical and health news from. Stay away from most mainstream media and alsoAmerican and British media as they are the most corrupted and unreliable these days. If they were that good and so reliable, we would nothave so any people dying in America and United Kingdom from COVID-19. Many of these same garbage media talked about the merits ofremdesivir etc in terms of saving lives in the past!Please help share these articles as certain American social media platforms like Twitter and also certain American search engines are tryingto curtail any news dissemination of any news that might be deemed negative with regards to the the COVID-19 vaccines. We at ThailandMedical News support vaccines but provided that proper studies and clinical trials have been conducted and that they are truly safe andeffective and we believe in reporting from a neutral perspective on both negative and positive aspects. отговор Сигнализирай за неуместен коментар

ing5rov
преди 3 години зелената гевендия може да бъде лакмус в случая ... гледай за каква кауза е платена , па си прави изводите ... отговор Сигнализирай за неуместен коментар

zelka007
преди 3 години пхахах ... *** ... това ли ти провереният и надежден източник ... ?!хаххахххаххахх аххахха аххахххахааааа ... ти ли си способният и начетен знайко , с големата уста и торбата акъл в задния джоб ... :)))))))))))) ... това ли ти е мястото дето пиеш амброзия ... ?!ако това ти е първоизточникът на информация , сметай какъв ти е капацитета ... мислех , че khao те подценява с длъжността мияч . баце , според мен си надценен ... :))) отговор Сигнализирай за неуместен коментар

julian12
преди 3 години Експериментална ваксина с много неизвестни е безопасна?! Тоя може да си изтрие *** с дипломата и след това да я изяде. отговор Сигнализирай за неуместен коментар